| Jake Paul vs. Mike Tyson (2024) Self |
| With/In Volume 2 (2022) |
| Clifford the Big Red Dog (2021) Lucille |
| With/In Volume 1 (2021) (segment "Coco & Gigi") |
| Sesame Street: 50 Years of Sunny Days (2021) Self |
| For NYC (2020) |
| Have a Good Trip: Adventures in Psychedelics (2020) Self |
| Inside the Rain (2020) Dr. Holloway |
| The Last Thing He Wanted (2020) Alma Guerrero |
| Birds of Prey (and the Fantabulous Emancipation of One Harley Quinn) (2020) Renee Montoya |
| The Dead Don't Die (2019) Posie Juarez |
| Active Adults (2017) Zoe |
| De Puerto Rico para el mundo (2016) Self |
| Muhammad Ali: A Life (2016) |
| Five Nights in Maine (2016) Ann |
| Michael Jackson's Journey from Motown to Off the Wall (2016) Self |
| Stretch and Bobbito: Radio That Changed Lives (2015) |
| Puerto Ricans in Paris (2015) Gloria |
| Pitch Perfect 2 (2015) The View Host |
| Fugly! (2014) Zowie |
| The Hero of Color City (2014) Red (voice) |
| Gods Behaving Badly (2013) Persephone |
| The Counselor (2013) Ruth |
| Picasso Baby (2013) Self |
| Won't Back Down (2012) Breena Harper |
| Small Apartments (2012) Ms. Baker |
| Brooklyn Boheme (2012) Self |
| Lies in Plain Sight (2010) Marisol Reyes |
| Pete Smalls Is Dead (2010) Julia |
| The Other Guys (2010) Herself |
| Celebrity Habla (2009) Self |
| Big Pun: The Legacy (2009) Self |
| Do the Right Thing: 20 Years Later (2009) Self |
| Pineapple Express (2008) Carol |
| Go Diego Go!: Moonlight Rescue (2008) |
| The Take (2007) Marina De La Pena |
| Home (2006) |
| Just Like the Son (2006) Mrs. Ponders |
| ¡Yo soy Boricua, pa' que tú lo sepas! (2006) Herself |
| Jesus Children of America (2005) Ruthie |
| Les enfants invisibles (2005) Ruthie (segment "Jesus Children of America") |
| Lackawanna Blues (2005) Bertha |
| Happy Birthday Oscar Wilde (2004) Self |
| AFI's 100 Years... 100 Songs: America's Greatest Music in the Movies (2004) Self |
| What I Want My Words to Do to You (2003) Self |
| The Evolution of an American Filmmaker (2003) Self |
| From the 104th Floor (2003) narrator |
| The Making and Meaning of 'We Are Family' (2002) Self |
| Riding in Cars with Boys (2001) Shirley Perro |
| Human Nature (2001) Louise |
| King of the Jungle (2000) Joanne |
| The Road to El Dorado (2000) Chel (voice) |
| The 24 Hour Woman (1999) Grace Santos |
| Perdita Durango (1997) Perdita Durango |
| Subway Stories (1997) The Girl (segment "Love on the A Train") |
| A Brother's Kiss (1997) Debbie |
| Somebody to Love (1994) Mercedes |
| It Could Happen to You (1994) Muriel Lang |
| Fearless (1993) Carla Rodrigo |
| Untamed Heart (1993) Cindy |
| White Men Can't Jump (1992) Gloria Clement |
| Night on Earth (1991) Angela |
| Criminal Justice (1990) Denise Moore |
| Making 'Do the Right Thing' (1989) Self / Tina |
| Do the Right Thing (1989) Tina |